ExtraLife
Routes of administration, reconstitution, and cycling.
Different peptides require different delivery methods for optimal bioavailability. Subcutaneous injection is the most common and offers the best absorption for most peptides — a small insulin syringe is injected just under the skin, typically in the abdominal area. Nasal sprays work well for brain-targeting peptides (Selank, Semax) that need to cross the blood-brain barrier. Topical application (GHK-Cu) targets skin and local tissue. Oral forms exist but generally have much lower bioavailability.
Match the route to the peptide: subcutaneous for systemic effects, nasal for brain-targeting, topical for skin — the right delivery method dramatically affects efficacy.
Most injectable peptides come as lyophilized (freeze-dried) powder that must be reconstituted with bacteriostatic water before use. The reconstitution process requires sterile technique: clean the vial tops with alcohol, slowly inject the water down the side of the vial (never directly onto the powder), and gently swirl — never shake. Reconstituted peptides must be refrigerated and typically last 4-6 weeks. Never freeze reconstituted peptides.
Proper reconstitution and cold storage are essential — peptides are delicate molecules that degrade quickly if mishandled or stored incorrectly.
Most peptide protocols involve cycling — taking the peptide for a set period, then taking a break before resuming. Cycling serves multiple purposes: it prevents receptor desensitization (where your cells become less responsive), allows your body to consolidate the healing or enhancement effects, and reduces the risk of side effects from prolonged use. Common cycling patterns include 5 days on / 2 days off, or 8 weeks on / 4 weeks off.
Cycling prevents receptor desensitization and allows your body to consolidate benefits — never run peptides continuously without planned breaks.